Egypt relies heavily on wheat as one of the major agricultural crops, accounting for the largest share of the country's agricultural output. As a result, it is crucial to enhance wheat productivity in Egypt to support the economy and society. Therefore, this study aimed to evaluate the impact of applying different organic fertilizers, including plant residue compost, cow waste compost, and a combination of both at the dosage of 10 ton ha^-1, besides the foliar application of amino acids (arginine, glycine, and tryptophan) at a rate of 100 mg L^-1 on wheat growth and productivity, as well as some soil properties. The study compares the treatments to a control group with no organic fertilizers addition and no foliar application. The compost from a combination of plant residue and cow waste was found to be the most effective treatment for promoting growth performance and productivity. The second most effective treatment was using the compost of plant residue alone, followed by the compost of cow waste alone. In contrast, the control treatment gave the lowest growth performance and productivity. In terms of amino acids, arginine, glycine, and tryptophan were all found to significantly enhance growth performance and productivity compared to the control treatment. Arginine was found to be the most effective, followed by glycine and then tryptophan. Therefore, the use of the mixed compost of plant residue and cow waste and amino acids (especially arginine) is recommended for wheat cultivation in Egypt to enhance productivity and support the economy and society.