The current study aims to estimate the biological impact of methanol, ethyl acetate, and hexane extracts of Tribulus terrestris leaves on different stages of Culex quinquefasciatus. A range of concentrations of methanolic (150-250-500-600-700 ppm), ethyl acetate (62.5-150-250-500-700 ppm) and hexane extracts (5-15-30-62.5-125-250 ppm) were evaluated. The results showed that methanol extract had the strongest effect on all stages of the mosquito compared to the ethyl acetate and hexane extracts. The methanol extract eliminated the larvae at a concentration of 700 ppm by 100%, with high values of LC₅₀-LC₉₀., while in ethyl acetate extract the highest mean larval mortality was at the highest concentration (700 ppm) but at a mean percent of 69.63 ±4.18. Also, the highest larval mortality rate was at the highest concentration of hexane extract at 94.467±1.86%, The findings suggest that the T. terrestris plant extract had strong effect on the different developmental stages of C. quinquefasciatus. In fact, more specialized future research is required to identify the active compounds in the plant that affect the vital processes in mosquitoes and use them as environmentally friendly alternatives.