Histological studies in the liver, lung and kidney of albino mice fed uninfested and infested wheat grains by granary weevil Sitophilus granaries were tested in the Agricultural Zoology laboratory of the Plant Protection Department, Faculty of Agriculture, Minia University, El-Minya, Egypt. Cross-section of the liver of an albino female fed healthy, uninfested grains, showed no bleeding or megakaryocytes. Sections in the liver of male albino mice fed on infested wheat grains by granary weevil S. granaries showed several megakaryocytes appeared in sinusoids as well as hemorrhage and congestion appeared in liver sections.Cross-section in the lungs of albino male mice fed healthy, uninfested grains, showed no focal chronic alveolitis. However histological studies on the lungs of albino mice fed infested wheat grains showed the thickness of alveolar walls with fibrosis, focal chronic alveolitis with fibrosis was likewise clear with a slight buildup of histiocytes around the terminal bronchiole and into the alveolar spaces.Bleeding inside bronchioles and outside alveoli also appeared. Moreover, kidney sections of male albino mice fed uninfested wheat grains by granary weevil showed normal kidney structure, while sections in kidneys of male albino mice fed infested wheat grains by granary weevil S. granarius showed many distortions of the tubules whose cuboidal cells are “vacuolated" with the absence of a clear brush border (microvilli) of the proximal convoluted tubules. Hemorrhage appeared inside and outside seminiferous tubules. Thus, the gained data exposed significant changes in the liver, lung, and kidney of male albino mice fed infested wheat grains with S. granaries.