Eggplant is economically highly rated in both Asia and Africa because of its richness in vitamins and antioxidants. The work purpose is to conduct a gap period, dietary risk assessment, and effect on some quality parameters of pymetrozine, pyriproxyfen, and acetamiprid on eggplant under greenhouse conditions. The QuEChERS method was appropriate for residue extraction for used insecticides. Recoveries ranged from 86 -105 % with relative standard deviation(RSD) rated from 1.52 to 10.26%. High-performance liquid chromatography (HPLC) was used for analysis. Pymetrozine, acetamiprid, and pyriproxyfen reached half-life by 1.15, 1.62, and 4.64 days consecutively. Pre-harvest interval guided to 3, 5, and 7 days for the three insecticides respectively. All tested insecticides decreased significantly the levels of chlorophyll a, chlorophyll b, N, P, and K content in leaves of eggplant compared with the control. Pyriproxyfen recorded the highest decrease. Pymetrozine and acetamiprid significantly decreased the total soluble solids(T.S.S.), ascorbic acid(vitamin C), carbohydrates, and total soluble sugars content in eggplant fruits compared with control, and did not significantly decrease total nitrogen, crude protein, and Fe content. Pyriproxyfen significantly decreased all parameters except % acidity and recorded the highest decrease compared with the control. Eggplant can be harvested safely after 3 to 7 days after application with tested insecticides. Risk quotient(RQ) was higher than 1 till the 5^th and 7^th day after application then became less than 1 for the rest of the tested interval days which indicates low long-term risk. The effect on plant quality needs to be studied in depth in future studies.