Aphis gossypii (Glover) (Hemiptera: Aphididae) and Gynaikothrips ficorum Marchal (Thysanoptera: Phlaeothripidae) are important economic insect pests in Egypt. They cause economic losses to many crops. Plant essential oils are less harmful to the environment, hypotoxic to mammals, and lower in cost in comparison with synthetic insecticides, and they have biological activity. This study aimed to investigate the efficiency of garlic and camphor essential oils, mineral oils, and chitosan against A. gossypii and G. ficorum as well as, to study their effects on the activity of some detoxifying enzymes such as GPT, GOT, GS-T, ALP and ACP. The obtained results indicated that garlic and camphor essential oils were more toxic against tested insects, A. gossypii and G. ficorum,compared with mineral oil and chitosan. According to the toxicity index of LC₅₀ and LC₉₀, the treatments were ranked first as camphor oil then garlic oil, mineral oil and chitosan in case of A. gossypii, while they ranked garlic oil then camphor oil, mineral oil and chitosan in case of G. ficorum. In general, all tested treatments caused high mortality percentages, ranging from 70 to 97% against A. gossypii and68 to 93% against G. ficorum at 10000 ppm after 48 hours of treatment. In addition, most of the estimated enzymes were inhibited by all treatments except some. Thus, the essential oils of garlic and camphor are gaining acceptance as a strategy for integrated pest management due to their safety and their high toxicity against A. gossypii and G. ficorum.