This study was conducted in potato fields at Banha city Qalyubia Governorate, during the 2022 and 2023 seasons where Senator (flonicamid), Chess (pymetrozine), and Closer (sulfoxaflor) insecticides were evaluated against Spodoptera littoralis and Aphis gossypii, and their associated predators. According to the results, pymetrozine was the most effective compound against the S. littoralis, followed by flonicamid, and sulfoxaflor was the least effective compound. The residual effect showed mortality percentage of cotton leafworm larvae ranging from 86.2 to 92.2% and 78 to 96.5% for the 2022 and 2023 seasons, respectively and the general mean reduction percentage for A. gossypii ranging from 86.5 to 86 % for season 2022 and 86.2 to 83.9 % for season 2023. The results clearly showed that the tested compounds caused a decrease of less than 50% in the numbers of the biological enemies associated with them (Coccinella undecimpunctata and Chrysoperla carnea) after treatment during the two seasons. Therefore, the tested insecticides were less harmful to predators and had an effective effect on the pests under study.