Spodoptera frugiperda (J.E. Smith) is a polyphagous pest that attacks different cultivated crops and causes serious damage. The destructive stage is the larval stage, whose caterpillars consumes the host plants' reproductive and vegetative components and cause high grain yield loss. The present work aims to study the efficient of some environmentally friendly compounds (XenTari 54% WG "Bacillus thuringiensis", Orange oil, Garlic Oil, Plesiva star 60% WG and Tracer 24% SC) of managing fall armyworm S. frugiperda larvae and their effect on resistance enzymes. revealed that the mortality percentage of the Plesiva star 60% WG recorded the highest reduction percentage 56.8% and the lowest reduction was XenTari 54% WG treatment recorded the 6.6%. According to statistical analysis there are significant differences between the 20 treatments whereas the mean of reduction percentage to S. frugiperda 4th larvae instar after spraying, divided into 18 groups. In terms of how the tested compounds affected the activities of certain enzymes, it was found that, in comparison to the control, the activity of the invertase enzyme was considerably decreased by five of the investigated compounds. The enzyme phenoloxidas all treatments resulted in the inhibition were significant differences between the control and every other course of action. However, there were no appreciable variations between Plesiva star 60% WG and garlic oil. Phenoloxidase enzyme activities showed inverse significant correlation with the total corrected mortality percentage whereas r=0.77, Data showed a considerable increase in acetylcholinesterase activity in the larvae of S. frugiperda under five treatments; compared to the control.