Psammotermes hypostoma Desneux considered one of the most dangerous pests in Egypt is which can harm any cellulose-containing materials. Pesticide resistance may develop as a result of the extravagance of using pesticides to avoid infection of termites and to avoid the dangers of resistance, it is a must to change the traditional methods and use the featured effective, innovative focusing on countermeasure techniques. Thus, using a combination of green nanoparticles and an aqueous extract of chlorpyrifosinsecticide, Datura stramonium, Nerium oleander, Poinciana regia, Citrullus coloroynthis and Calotropis procera with the appropriate salt (silver nitrate) would be more effective against P. hypostoma. The obtained results showed that chlorpyrifos was most hazardous substance, while C. procera was the lowest toxic one, however, D. stramonium, N. oleander, P. regia, C. coloroynthis came in between. According to these findings, all the compounds and extracts were much more lethal to P. hypostoma workers than the pesticide chlorpyrifos, and they can be utilized as a low-cost substitute in future IPM programs to combat P. hypostoma.Data showed that 35.86, 29.77, 26.31, 23.82, and 12.94 fold as effective as chlorpyrifosat the LC₅₀ level. The results revealed that the toxicity of pesticides for termites in decreasing order as follows: chlorpyrifosinsecticide> D. stramonium > N. oleander > P. regia > C. coloroynthis > C. procera.