The experiments were conducted at the laboratory of Entomology belonging to the Economic Entomology Department, Faculty of agriculture, Mansoura University. The developmental period, progeny weight loss, and susceptibility of maize varieties to Rhyzopertha dominica (Fab.) (Bostrichidae: Coleoptera) was determined through the free-choice and non-choice tests among maize varieties. In addition, the chemical composition of the tested varieties was estimated in relation to variety susceptibilities to this insect. The longest development period (29.4 ± 0.04 days), the lowest progeny production in the first and second generations (19.4 ± 1.21 and 33.2 ± 0.58 individuals), and the lowest weight loss of grains in the two generations (0.33 ± 0.03 and 0.45 ± 0.02 grams) by R. dominica was occurred on the Single cross 132 (S.C. 132) variety. Whereas The Single Cross 178 (S.C.178) exhibited the lowest attractiveness to R. dominica This low attractiveness of the single Cross 178 (S.C.178) is due to the low amounts of protein, fiber, total carbohydrates, calcium, zinc, iron ash, and magnesium.