The study was carried out at a field experiment of the Faculty of Agriculture, Kafr Elshiekh University, Egypt, during the 2019/2020 and 2020/2021 growing seasons aimed to study the impact of Urea fertilizer application levels and micronutrient applications on wheat productivity in the North Delta region. The experimental design was a split-split plot with three replications, the experiment involved soil application of urea at levels i.e., 25, 50, and 75 kg N fed-1. (feddan=4200 m2) allocated in main plots, and foliar application of micronutrients (Fe, Mn, Zn and Cu) allocated in the sub-plots. Five wheat cultivars (Shandaweel 1, Misr 2, Misr 3, Sakha 95 and Giza 171)were assigned to sub-sub plots. Results indicated that significant increases in days to heading (100.4 days) and maturity (147.3 days), plant height (91.4 cm), number of fertile tillers m-2 (265), TGW (45.3 g), grains spike-1 (64.5), grain yield (2.211tons fed.-1) and protein content (14.0%) with the highest nitrogen fertilizer rate and M2 micronutrient ( Fe = 300 mg L-1, Mn = 100 mg L-1, Zn = 50 mg L-1 and Cu = 50 mg L-1). Giza 171 exhibited superiority for heading and maturity days, fertile tillers, and TGW. Sakha 95 recorded the highest biological and grain yield (10.844 and 3.477 tons fed-1.) respectively, while Giza 171 yielded 7.420ton fed.-1 straw, and Misr 3 showed superior protein content (13.51%). Increased nitrogen fertilizer and micronutrient application, along with specific cultivars, enhanced most traits, with Giza 171 and Sakha 95 demonstrating superior grain yield, components, and quality.