A field trial was carried out through the two consecutive wheat growing times of year, 2020/21 and 2021/22, at Sakha Agriculture Research Station in Kafr El-Sheikh Governorate, situated in the middle northern region of the Nile Delta area. The study aims to determine the most critical growth stage of some wheat cultivars ( Misr 1, 3, Sakha 95, Giza 171, Gemmeiza 9,and 10) for skipping watering. Furthermore, five irrigation treatments were implemented ; Treatment A, involved full irrigation, with no skipping of irrigation at any growth stage. Treatments B, C, D, and E involved skipping irrigation at the tillering, elongation, booting, and milking stages, respectively. Obtained results revealed that Sakha 95 followed by Giza 171 are the most suitable wheat cultivars for the area of study. The control treatment, which involved full irrigation, exhibited the greatest crop return, yield components, and water associations. Skipping irrigation at the milking stage is more tolerant to skipping watering.The crop-water function of PIW and WP were analyzed. Suitable wheat cultivars should be cultivated in the middle north of Nile Delta area are Sakha 95, Giza 171 and Gemmeiza 9 under this investigation. The study recommends that the Sakha 95 variety, followed by Giza 171 and Gemmeiza 9, are the most suitable for the northern Delta region of Egypt. When irrigation water is available, we recommend not preventing irrigation at any stage of growth. In the event of a shortage of irrigation water, irrigation can be prevented in the milky phase, as the crop loss is very slight.