In order to improve growth, yield components and chemical constituents of safflower plants a field experiment was done at a privet farm in Mansoura, Dakahlia Governorate, Egypt, during winter seasons of 2021/2022 and 2022/2023. Two factors in this experiment were examined, potassium rate (0.0, 24, 48 and 72 kg K2O/feddan) and amino acids types (control, L-tryptophan, phenylalanine and L-tryptophan + phenylalanine each at 150 ppm) as well as their combination treatments. The achieved results indicated that increasing potassium fertilizer rates gradually increased plant height, branch number per plant and total dry weight of safflower, seed yield per plant and /feddan and fixed oil and petals yields per feddan as well as total chlorophyll contents and carthamin content. The highest values in this regard were obtained when plants fertilized with 72 kg K2O/feddan compared to the other rates under study. In addition, utilizing L-tryptophan + phenylalanine each at 150 ppm significantly increased growth and productivity of safflower plants compared to control (un-sprayed plants) and each one individually. Generally, the best combination treatment for improving seed, fixed oil and carthamin yields were achieved with the treatment of L-tryptophan acid + phenylalanine each at 150 ppm and fertilized with 72 kg K2O/feddan.