This study was performed at El-Gemmeiza Agricultural Research Station (ARC), El- Gharbia Governorate, Egypt, during 2019/2020 and 2020/2021 growing seasons to evaluate effects of three irrigation intervals on grain yield and yield components and water use efficiency of ten wheat cultivars. Four replications of a split-plot design were carried out, the main plots were included three irrigation intervals i.e., irrigation every 20, 30 and 40 days  and the ten bread wheat cultivars i.e., Giza171, Sakha 95, Sids14, Misr 3, Giza 168, Misr 2, Gemmeiza 11, Sakha 94, Shandweel 1 and Gemmeiza 12 were placed in sub-plots. Irrigation intervals every 20 days recorded the highest significant values of all the studied characters except for grain protein percentage and water use efficiency that recorded highest values by irrigation intervals every 40 days in the two growing seasons. Misr 3 cultivar recorded the highest 1000-grain weight, number of spikes/m², grain weight/spike, grain and biological yields/fad in the two seasons. While, Gemmeiza 11 generated the tallest spike and the highest protein content in the grain during the two seasons. Irrigation Misr 3 every 20 days produced the highest spike/m², biological yields and grain yield per fad in the second season. While irrigating Gemmeiza 11 and Shandweel 1 every 20 days resulted in the best water consumption use in the two seasons. Finally, a positive correlation and significant relationships were detected between grain yield/fad and all yield attributes. It could be concluded that growing Misr 3 cultivar with irrigation every 20 days can achieve high grain yield and water use efficiency under middle delta zone conditions.