This study was performed at El-Gemmeiza Agricultural Research Station, El- Gharbya Governorate, Egypt, during 2019/2020 and 2020/2021 seasons to study the impact of eight fertilizer treatments, i.e. B1 (Zero fertilizer), B2 (75 Kg N fed-1), B3 (50 Kg N fed-1 + 5 Kg fed-1 Blue-green algae), B4 (50 Kg N fed-1 + 5 Kg fed-1Azotobacter), B5 (25 Kg N fed-1 + 5 Kg fed-1 Blue-green algae + 5 Kg fed-1Azotobacter), B6 (5 Kg fed-1 Blue-green algae + 5 Kg fed-1Azotobacter), B7 (5 Kg fed-1 Blue-green algae) and B8 (5 Kg fed-1Azotobacter) were evaluated on grain yield and wheat growth of three bread wheat cultivars (Misr 3, Sakha 95 and Sids 14) . Wheat cultivars significantly differed in all traits. Misr 3 wheat cultivar recorded the highest number of spikes/m2, 1000 grains weight, biological yield, grain yield, harvest index and chlorophyll content in both seasons. B4 recorded a significant increase in the number of spikes/m2, 1000 grains weight, grain yield, harvest index and chlorophyll a& b. Results exhibited that the interaction effect between fertilizer treatments and wheat cultivars had a significant effect on the number of spikes/m2, grain yield, harvest index and chlorophyll content. The results indicated that Misr 3 gave the highest grain yield in both seasons under bio and mineral fertilizer treatments followed by Sakha 95 and Sids 14. Thus, the application of bio and mineral fertilizers significantly increases wheat grain yield and plant growth. Also, it enhanced all studied parameters.