Field trials were conducted at Sers El-Layin Agriculture Research Station, Agricultural Research Center (ARC), Minufiya Governorate, Egypt, during the 2021 and 2022 seasons. The current study evaluates the response of intercropping system cowpea/maize to potassium fertilizer and boron foliar application on the productivity of both crops and monetary advantage. The experiment was laid out in a randomized complete block design using a split-plot arrangement with three replicates. Three potassium fertilizer levels (0, 30 and 60 kg/fed) were assigned to the main plots. while the sub-plots were allocated to three foliar applications of boron levels (0, 350 and 700 g/fed). These results indicated that the application of Potassium 60 kg/fed + Boron 700 g/fed produced the maximum yield and its maize components, as well as fresh forage of cowpea as compared to the other treatments. Competitive proportion and yield advantages indicated that all treatments had higher productivity advantages compared to monoculture. Maximum values of land equivalent ratio (1.70), monetary advantage index (8672 L.E./ fed), as well as gross revenue (21061 L.E./fed) were obtained when cowpea intercropped with maize with combined fertilization (60 kg/fed of K + 700 g/fed of B) compared to the gross revenue of the sole cropping of maize and cowpea (15070 and 8079 L.E. fed-1), respectively. Thus, applied at 60 Kg/fed of potassium and 700 g/fed of boron is considered appropriate and economical during intercropping of cowpea and maize to improve crop production and provide economic advantages for small farmers.