The potting experiment was conducted during 2018/2019 and 2019/2020 seasons at the Experimental of Floriculture Farm, Department of Horticulture, Faculty of Agriculture, Benha University to find out the influence of planting date and the mixture of growing media on improving and enhancement of the root growth characteristics of Euphorbia milii cuttings. Results showed that growing Euphorbia milii cuttings in the autumn and amid a mixture containing clay +perlite +peat moss (1:1:1  v:v:v) produced the highest number of roots/ cutting, rooted cuttings /medium,  root length / cutting, rooted cuttings percentage and number of leaves /cutting. followed by a mixture of clay + sand + peat moss + perlite (1:1:1;1  v:v:v:v) .Whereas clay+ perlite (1:1 v:v) in the autumn  ranked the third value in this concern. Conclusively, growing of  Euphorbia milii cuttings in a potting medium containing clay +perlite +peat moss in (autumn) produced the best rooting quality of Euphorbia milii cutting.