In order to investigate the impact of foliar fertilization treatments (NPK fertilizer, nano-fertilizer, salicylic acid (SA) and proline acid and its mixture) on productivity and grain quality of wheat cultivar (Sids-14), two field experiments were conducted at a private farm in Ezab El-Arab Village, Aga District, Dakahlia Governorate, Egypt, during the 2020–2021 and 2021–2022 seasons. Under three irrigation treatments, the plants were given four irrigations (control), three irrigations were given while the second irrigation was skipped, and three irrigations were given while the final irrigation was withheld. The trials utilized a strip-plot design with three replications. The yield, its components, and the grain quality characteristics of wheat were drastically reduced throughout the course of the two growing seasons by missing the second irrigation or withholding the final irrigation. When spraying with a combination of NPK fertilizer + nano-fertilizer + SA + proline acid in both seasons, the greatest values of yield, its components, and grains quality characteristics of wheat were noted. Withholding the last irrigation (plants received 3 irrigations) and spraying a mixture of NPK fertilizer at the rate of 5 g/liter + nano-fertilizer at the rate of 0.75 ml/liter water + 200 ppm of salicylic acid at the rate of + proline acid at the rate of 200 ppm in each spraying under the environmental conditions of Dakahlia Governorate could be recommended in order to keep grain quality and high production, while simultaneously reducing water requirements.