Egyptian clover "Trifolium alexandrinum, L." is the most important forage crop in Egypt. The main objectives of the current study were to assess the differential response of two base populations of Egyptian clover to half-sib and S₁-families selection methods. At the fourth cutting, Sakha4 population, expressed the higher gains from half-sib family selection vs. Helaly population. The obtained values were 30.88 and 39.83% vs. 18.40 and 37.93% for the former and the later populations relative to base population (C₀) and the average of the checks, respectively. Meanwhile, S₁- family selection, expressed 44.12 and 53.97% in Sakha 4 population, relative to base populations (C₀) and the average of the checks, respectively. However, 37.60 and 60.30% gains were presented by Helaly population, relative to base populations (C₀) and the average of the checks were 37.60 and 60.30%, respectively. Commonly, Sakha4 population was more responsive to any of the tested selection methods. This might indicate a higher level of variability within that population relative to Helaly population, which received much intensive improvement through selection, which limited the valuable variability.