Peppermint Mentha piperita ʺLamiaceae" is an aromatic plant has a strong sweetish odour used to add flavour or fragrance to foods in addition to its medicinal uses. Currently, the interest in expanding its cultivation in Egypt is considered necessary. Therefore,  a nutritional experiment (Lysimeter trial) was executed under a split-plot design aiming to investigate the effect of foliar spraying methionine (50 mgL^-1) and melatonin (50 mgL^-1) plus control treatment on the peppermint grown on different soils i.e., alluvial, sandy, calcareous and saline soils. The soil type represented the main factor, while the foliar applications were devoted to sub-plots. Growth criteria i.e., plant height (cm), No. of leaves, fresh and dry weights (g plant^-1& Mg h^-1, 1.0 Mg ʺmega gramʺ=10⁶ g i.e., metric ton) and essential oil (%) were measured at the first and second cut times. While, photosynthetic pigments i.e., chlorophyll (mg g^-1 F.W) and carotene (mg g^-1F.W) and quality traits i.e., carbohydrates (%) and vitamin C (mg 100g^-1) were determined at the second cut time only. The values of all aforementioned traits indicated that peppermint cultivation thrived in sandy soil followed by alluvial soil, while its performance was low under both calcareous and saline soils conditions, respectively. Regarding foliar applications, the methionine treatment was superior compared to melatonin, while the control treatment came in the last order. Generally, it can be concluded that the foliar spraying of both methionine and melatonin can improve the performance of peppermint grown on different soils, including degraded soils e.g., calcareous and saline.