Background: Breast cancer represents the most frequently diagnosed cancer affecting women globally and is the second leading cause of cancer death among women, following lung cancer. Similarly, in Egypt, breast cancer is the most prevalent form of cancer in women, constituting 35.1% of all female cancer cases. Aim: This study describes the clinico-epidemiological and pathological pattern of breast cancer, including the analysis of investigational methods and treatment lines. Patients and methods: This retrospective descriptive Hospital based clinico-epidemiological study was held at Clinical Oncology Department, Tanta University Hospitals for patients who were histo-pathologically proven to have breast cancer presented at our department throughout the period between January 2019 to 31th December 2021. Results: this study included 1210 patients who had breast cancer over period from 2019 to 2021 at our department. Breast cancer cases represented about 20% of all cases in each year. The mean age was 53 (range 24 -90) years. Postmenopausal patients represented 63%. Patients presented with stage II were 43%. The most common subtype was IDC (88%). Most cases were luminal B (48.4%). At the time of study termination, 19.7% of non-metastatic patients developed metastasis whether solitary or multiple and bone was the most common site of metastasis followed by lung and 94.5% of all patients were alive. Conclusion: Breast cancer is a heterogenous disease and the treatment differs according to molecular type and stage. Early stage breast cancer had a good survival than late stage. Luminal cases had better survival than triple negative and HER2 positive cases