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385516

Dosimetric Comparison between Simultaneous Integrated Boost Dynamic Conformal Arc Therapy and Whole Brain Radiation Therapy Techniques in Treatment of Patients with Multiple Brai

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Natural/synthetic agents in anti-cancer therapy

Abstract

Background: Whole Our study aims to compare between the dosimetric results and treatment delivery efficiency of Whole Brain Radiation Therapy (WBRT) versus Simultaneous Integrated Boost Dynamic Conformal Arc Therapy (DCAT) planning techniques – to explore which is the better technique in brain metastases treatment. Methods: WBRT and DCAT plans were created for 20 patients treated for brain metastases using the Eclipse™ treatment planning system (Varian Medical Systems). The WBRT plan was planned to deliver 20 Gy to the planning target volumes (PTVs) in 5 fractions, while DCAT plan was planned to deliver the PTVs 25 Gy in 5 fractions. Target coverage and organs at risk (OARs) sparing were compared in both techniques. The number of delivered monitor units (MUs) and the treatment time were also used to assess the efficiency of each plan. Results: The study results revealed better Planning Target Volumes (PTVs) dose coverage in the DCAT plan compared to WBRT, while maintaining significantly lower OAR doses. Conclusion: DCAT plans deliver higher doses to brain metastases and minimal doses to OARs. Therefore, dose escalated DCAT for small and large lesions allow higher radiotherapy doses to be delivered to small and larger lesions, all while maintaining safe doses to the surrounding OARs.

DOI

10.21608/jcbr.2024.298063.1358

Keywords

brain metastases, Arc therapy, Whole brain radiotherapy, Radiotherapy planning

Authors

First Name

Ahmed

Last Name

ElDrieny

MiddleName

M

Affiliation

pharos university, Alexandria, Egypt

Email

ahmed.eldrieny@pua.edu.eg

City

Alexandria

Orcid

-

First Name

Ahmed

Last Name

Ahmed

MiddleName

Adel

Affiliation

Ayadi Almostakbal Oncology Hospital, Alexandria, Egypt. -Alexandria Clinical Oncology Department, Alexandria University, Alexandria, Egypt.

Email

a7med_adel99@yahoo.com

City

Alexandria

Orcid

-

First Name

Nayera

Last Name

Mahmoud

MiddleName

-

Affiliation

Alexandria Clinical Oncology Department, Alexandria University, Alexandria, Egypt.

Email

nayera.mahmoud2015@gmail.com

City

Alexandria

Orcid

-

First Name

Azza

Last Name

Darwish

MiddleName

-

Affiliation

Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Email

a.darwish9309@gmail.com

City

-

Orcid

0000-0002-7734-4632

Volume

8

Article Issue

3

Related Issue

49733

Issue Date

2024-09-01

Receive Date

2024-06-19

Publish Date

2024-09-01

Page Start

51

Page End

60

Print ISSN

3009-6391

Online ISSN

3009-7312

Link

https://jcbr.journals.ekb.eg/article_385516.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=385516

Order

385,516

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

Egyptian Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Dosimetric Comparison between Simultaneous Integrated Boost Dynamic Conformal Arc Therapy and Whole Brain Radiation Therapy Techniques in Treatment of Patients with Multiple Brai

Details

Type

Article

Created At

30 Dec 2024