The current article aims to compare the colon and the large intestine's histochemical and histomorphometric characteristics. The study included 20 animals, ten healthy male sheep and ten male rabbits; their weight were from 35-45 kg and 1.5-2.5 kg. Eosin and hematoxylin, a standard tissue approach, and periodic acid Schiff stains. Histologically, showed similarity in epithelium type of mucosa lining the cecum and colon in both animals, the epithelium lining was composed of simple columnar. Well-developed intestinal glands were abundant in the mucosa layer these gland simple tubular straight unbranched, and these glands compose goblet cells and columnar cells. In both animals, the submucosa layer of cecum and colon does not possess glands and lymphatic nodules. The mean thickness regarding these layers sub mucosa and muscularis in sheep cecum and colon were significantly (p<0.05) larger in comparison to rabbits' cecum and colon. There have been non-significant (p<0.05) differences among thickness mucosa sheep and rabbit in cecum and colon, where was thickness mucosa of cecum in sheep and rabbit (272.96±36.55),(237.96±24.09), while thickness mucosa of colon (604.24±252.58) (564.58±47.69). Intestinal glands were a strong reaction with PAS. Conclusions: The findings indicated similarities of herbivores species in histological features in cecum and colon of the sheep and rabbit.