Background: Cervical cancer ranks as the third most prevalent malignancy and leading cause of mortality among gynaecologic malignancies. Concurrent chemo-radiotherapy (CHT-RT) is the definitive treatment for locally advanced cervical cancer. Aim: to assess the gastrointestinal toxic effects and grade the toxicity after definitive chemo radiation, followed by intracavitary brachytherapy, in the treatment of locally advanced cervical cancer. Materials & Methods: This prospective research was conducted on 30 individuals, aged above of 18 years old, females, with locally advanced disease (stages IB3 to IVA). Results: Regarding Kaplan-Meier survival curve, the mean time of progression free survival was 10.18 m and % at the end of study was 76.7. Acute GIT toxicity grade 0and 2 were the highest followed by grade 1 then grade 3. There was a significant difference with hypertension (HTN) regarding demographic data of the patients in relation to abdominal pain/ discomfort, until now there is no explanation for this, and further prospective studies are needed to reveal this result, treatment in relation to diarrhea and nausea in relation to sigmoid dose. Conclusion: There was significant relation between gastrointestinal toxicity and the dose and the site of brachytherapy, which nausea toxicities were related to dose of sigmoid. Also, diarrhea toxicities related with median volume of rectum.