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325128

The Outcomes of Concomitant Hypofractionated Simultaneous Integrated Boost Intensity-Modulated Radiotherapy Plus Concurrent Weekly Cisplatin monotherapy for Newly Diagnosed Local

Article

Last updated: 04 Jan 2025

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Abstract

Aim of the work: to evaluate outcome of Concomitant Hypofractionated Simultaneous Integrated Boost (SIB) Intensity-Modulated Radiotherapy (IMRT) Plus Concurrent Weekly Cisplatin monotherapy for Newly Diagnosed Locally Advanced Cancer Cervix with Positive LNs in elderly patients. Patients and methods: twenty-one patients were included diagnosed with locally advanced cancer cervix ≥ 65 years old with good performance status and adequate organ functions. Eligible patients received concomitant chemotherapy in form of cisplatin monotherapy (40 mg/m2) weekly, during radiotherapy treatment in form of External Beam Radiotherapy (EBRT) with SIB due to patients` refusal or inability to receive brachytherapy (BRT). Treatment toxicity, progression free survival (PFS) and overall survival (OS) were recorded and analyzed. Results: The median age reported was 70 years, (range: 65-76 years) and the median follow up period was 35 months (ranged from 18-47 months). The OS was 90.2% at 2 years and 76.8% at 3 years. The median time to progression was 27 months (ranged from11 – 46 months). The PFS was 75.6 % at 2 years and 63.5% at 3 years. Conclusion: in locally advanced cervical cancer, SIB-IMRT could be considered an effective and safe treatment alternative in elderly patients or unavailable brachytherapy.

DOI

10.21608/jcbr.2023.227456.1310

Keywords

Keywords: cancer cervix, Radiotherapy, SIB, IMRT

Authors

First Name

sara

Last Name

darwish

MiddleName

A.

Affiliation

clinical oncology department, Tanta university

Email

sarazaghloul84@yahoo.com

City

tanta

Orcid

-

First Name

Asmaa

Last Name

Elkady

MiddleName

-

Affiliation

Clinical Oncology Department, Tanta University, Egypt.

Email

asmaa.elkadi@med.tanta.edu.eg

City

tanta

Orcid

-

Volume

7

Article Issue

3

Related Issue

42807

Issue Date

2023-09-01

Receive Date

2023-08-06

Publish Date

2023-09-01

Page Start

77

Page End

84

Print ISSN

3009-6391

Online ISSN

3009-7312

Link

https://jcbr.journals.ekb.eg/article_325128.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=325128

Order

325,128

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

Egyptian Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

The Outcomes of Concomitant Hypofractionated Simultaneous Integrated Boost Intensity-Modulated Radiotherapy Plus Concurrent Weekly Cisplatin monotherapy for Newly Diagnosed Local

Details

Type

Article

Created At

30 Dec 2024