Drug discovery and development together are the complete practice of identifying a new drug and passing it to market. It covers all areas of cancer biology, from cell signaling pathways to tumor hypoxia and from angiogenesis to cell death pathways. The Egyptian Association for Cancer Research (EACR) successfully organized its annual international conference under the theme of “Anti-Cancer Drug Discovery, 21-22 April 2019 at Tanta University convention Center, Egypt. ACDD-2019 was an excellent opportunity to gather national researchers and international researchers from the USA, China, Japan, KSA, and other countries to share their interest in drug discovery and development. The conference included 3 main sessions on day 1 and 8 sessions on day 2. Day 1 included 13 keynote speakers covering different subjects in anti-cancer drug discovery and based on nanoparticles, gene therapy, immunotherapy, and natural and synthetic compounds. Day 2 focused on the roles of the center of excellence of scientific research in drug discovery, parasite and marine compounds and cancer, natural and synthetic anti-cancer drugs, molecular oncology and cancer stem cells, and cancer immunology and immunotherapy. About 600 participants attended the conference including undergraduate and postgraduate students as well as faculty members from different colleges, universities, and research centers in Egypt. ACDD-2019 (http://acdd.tanta.edu.eg/) represented an outstanding opportunity for sharing thoughts and ideas for collaborative research in anti-cancer drug discovery and development from chemical synthesis to the clinic.