Background: The growing research focus on aggressive behavior in individuals with psychiatric disorders is gaining significant attention, and it is essential to gain a deeper understanding of the variables linked to predicting aggression to enhance treatment and prevention strategies. Aim: The present study intends to assess the relationship between sense of coherence, alexithymia, and aggression among psychiatric patients. Subjects and Method: Utilizing a correlational research design, socio-demographic & clinical questionnaire, Sense of Coherence Questionnaire (SOC-13), Toronto Alexithymia Scale (TAS-20) and brief aggression questionnaire— (BAQ) in a sample of 200 psychiatric inpatients. Results: Most patients exhibit elevated levels of aggression and alexithymia and Low Sense of Coherence. Conclusion: There were strong statistically significant negative correlations between Sense of Coherence with both aggression and alexithymia. Notably, aggression and alexithymia were found to have a highly statistically significant positive correlation. Recommendation: A training program designed for patients with alexithymia will incorporate psychological interventions and cognitive training to help them recognize and articulate their emotions and feelings more effectively.