Background: Mechanically ventilated patients (MVPs) who enter intensive care units (ICUs) suffer from immobility and prolonged bed rest, which have negative consequences on hemodynamic parameters. Aim: The study aimed to assess hemodynamic parameters for mechanically ventilated patients. Subjects and Method: The study design used was descriptive. A purposive sample of mechanically ventilated adult patients (555) was recruited from the intensive care units of Egypt Health Care Authority Hospitals in Port Said City, including El-Salam, Al-Zhour, and El-Shefaa Medical Complex. Data collection tools: Tool I: Patients' Health Profile includes Part 1: Patients' data, and Part 2: Patients' health assessment. Tool II: Hemodynamic parameters assessment. Results: The study illustrated that the mean score of  heart rate score, respiratory rate,  diastolic and systolic blood pressure, mean arterial pressure, pulse pressure, central venous pressure, averages increased during assessment due to altered health, and patient tolerance to stressors as mechanically ventilated, while the mean score of arterial blood gases and percutaneous oxygen saturation remained stable among mechanically ventilated patients. Conclusion: The current study revealed a remarkable increase in the mean scores of most hemodynamic parameters in mechanically ventilated patients. Recommendation: This study suggested a passive exercise therapy program as part of the general management of mechanically ventilated patients and should be incorporated into daily clinical practice in intensive care units to improve hemodynamic parameters.