This study was conducted on broiler chicks (Ross-308) to evaluate the influences of using probiotics and enzymes in diets on growth performance and some blood parameters. A total number of 135 one-day-old broiler chicks were randomly obtained and divided into three equal groups; each group consisted of three replicates of 15 chicks. Experiment was lasted to 35 days of age. First group (C) designated as control and was given only basal diet (Table 1), while the 2^nd (P) and the 3^rd (E) groups were received probiotic (Guardizen-M) and enzymes (Fra^®Multizyme) at the levels of 1g and 0.5g/kg in diets, respectively. Data indicated that body weight BW and feed conversion ratio FCR were significant (P<0.05) better for birds in P group, followed by those in E group, while the lowest (P<0.05) values were noticed in control one. Feed consumption FC was significantly (P<0.05) decreased in P group, followed in E group, while the highest (P<0.05) value were noticed in control one. Moreover, P and E groups had the highest (P<0.05) body weight gain BWG as compared to control group. All studied blood parameters significantly (P<0.05) improved in group of P, followed by E group compared with control one. Finally, it could be concluded that adding of 1g probiotic (Guardizen-M) or 0.5g enzymes (Fra^®Multizyme)/kg in diets of broiler chicks (Ross-308) could be recommend for high growth performance and improve blood parameters.