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295621

Impact of Frailty Assessment on The Outcome of Acute Myeloid Leukemia in Elderly Patients

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Last updated: 03 Jan 2025

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Abstract

Background: Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. The incidence of AML increases with age. According to the Surveillance, Epidemiology, and End Results Program, over 57% of new cases of AML occur in adults aged 65 years or above (65–74 years: 23.7%; 75–84 years: 22.8%; and >84 years: 10.6%). Objectives: The objective of our study is to implement an applicable and representative frailty assessment tool for newly diagnosed elderly AML patients that helps the treating physician in choosing the optimal treatment decision. Patients and Methods: This prospective observational study was conducted in clinical hematology and bone marrow transplantation unit, Ain Shams university hospitals, Cairo, Egypt. The study included 32 newly diagnosed AML patients, aged ≥ 60 years and categorized into frail and non-frail groups using G8 and GAH Scores. The initial frailty scoring was correlated with the patients’ outcome after 6 months, with the routinely used performance status score and the known disease prognostic markers. Results: We compared frail and non-frail groups regarding differences in mean age, molecular cytogenetic classification, hospital stay, response to treatment, and mortality rates. Frail patients had an older mean age, more favorable risk molecular cytogenetics, shorter hospital stays, poorer response to treatment, and higher mortality rates. The study also found that survival was lowest in patients with subtype M3. However, the overall incidence of complications did not show a significant correlation with frailty assessment or type of chemotherapy. Conclusion: Both G8 and GAH scores strongly predicted survival, independently of age, markers of disease risk, type of induction therapy. Our findings support using the G8 and GAH as an initial frailty assessment tool for newly diagnosed AML elderly patients. G8 is an easy to implement frailty assessment tool that should be widely implemented for elderly patients with hematological malignancies.

DOI

10.21608/ejhbmt.2023.295621

Keywords

Frailty, AML, prognosis

Authors

First Name

Tamer

Last Name

Ahmed

MiddleName

-

Affiliation

Internal Medicine & Hematology, Faculty of Medicine, Ain Shams University

Email

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City

-

Orcid

-

First Name

Mostafa

Last Name

El Razzaz

MiddleName

-

Affiliation

Internal Medicine & Hematology, Faculty of Medicine, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Basma

Last Name

Mansour

MiddleName

Saeid

Affiliation

Internal Medicine & Hematology, Faculty of Medicine, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Hebatullah

Last Name

Magdy

MiddleName

-

Affiliation

Internal Medicine & Hematology, Faculty of Medicine, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Ramadan

Last Name

Moussa

MiddleName

-

Affiliation

Internal Medicine & Hematology, Faculty of Medicine, Ain Shams University

Email

-

City

-

Orcid

-

Volume

10

Article Issue

11

Related Issue

40878

Issue Date

2023-04-01

Receive Date

2023-04-16

Publish Date

2023-04-01

Page Start

1

Page End

2

Print ISSN

2356-9735

Article File

EJHBMT_Volume 10_Issue 11_Pages 1-2.pdf

PDF . 91.2kB

Link

https://ejhbmt.journals.ekb.eg/article_295621.html

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https://ejhbmt.journals.ekb.eg/service?article_code=295621

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Original Article

Type Code

726

Publication Type

Journal

Publication Title

Egyptian Journal of Hematology and Bone Marrow Transplantation

Publication Link

https://ejhbmt.journals.ekb.eg/

MainTitle

Impact of Frailty Assessment on The Outcome of Acute Myeloid Leukemia in Elderly Patients

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Type

Article

Created At

30 Dec 2024