Background: Nurse–physician collaborative behaviors is a process of interaction between nurses and physicians during the delivery of patient care through using open communication, working cooperatively, sharing responsibility for managing conflict, solving problem, and performing joint decision-making. Aim of the study: It aimed to assess the nurse-physician collaboration and its' relation to professional autonomy and team commitment among nurses. Research design: A descriptive correlational design was used to carry out this study. Setting: The study was conducted at Dar El Sheffa hospital. Subjects:  The study subjects included 210 out of 460 nurses. Tools: Data were collected by using: Nurse - physician collaboration scale. Professional autonomy scale. Team commitment scale: Results: more than half (54.8%) of studied nurse had high perception level regarding total Nurse – Physician Collaboration. And more than half (57.1%) of them had high perception level regarding total professional autonomy. Also more than half (52.4%) of studied nurses had  high perception level regarding total team commitment. Conclusion: there was highly statistical positive strong correlations between total Nurse – Physician Collaboration and professional autonomy, and team commitment among nurses. Recommendations: Providing an inter-professional collaborative environment as a vital part of healthcare organization development to promote nurses' performance as well as improve patient safety climate.