Background: Testicular cancer is the most common type of cancer in the urogenital system in men aged 15-34, ranging from as low as 1.86/100,000 prevalence in Egypt. Early detection of testicular cancer can be achieved by testicular self-examination (TSE). Aim: the study aimed to assess the adult male awareness regarding testicular self-examination for early detection of testicular cancer. Design: A descriptive correlational research design was utilized in this study. Setting: The study was conducted at outpatient clinic of Dermatology and Andrology at El Demerdash Hospital as affiliated at ain shams uniiversity. Subjects: A purposive randomly sample (270) adult males from mentioned setting were included. Data collection tools: Structured interviewing questionnaires were used for the data collection which include four parts: Socio-demographic characteristics, adult male Knowledge, practices, and attitude regarding testicular self-examination. Results: 67.0% of the studied adult male achieved satisfactory level of knowledge about testicular self-examination, 80.4 % of the studied subjects have done above 60% of the practice related to testicular self-examination, which is considered satisfactory level of practice, and38.5% of the studied adult males have positive attitude toward testicular self-examination. Conclusion: this study concluded that more than two thirds of adult male had satisfactory level of total knowledge and satisfactory level of practice, whereas more than half of them had negative attitude toward testicular self-examination for early detection of testicular cancer. Recommendations: Creating effective National Public Awareness Campaigns, interactive social media and internet tools to educate young people who are most at risk. And develop audiovisuals and pamphlets as supportive materials.