Background: Adults are more likely to suffer from sleep problems, such as obstructive sleep apnea (OSA), with three out of four exhibiting symptoms of the condition. More than three quarters of patients with OSA are thought to go undetected which significantly impacts patients' general health. Aim: The aim of the current study was to evaluate the effect of sniffing versus side lying position on obese patients with obstructive sleep apnea. Design: Time-series quasi-experimental design was used to achieve the aim of the current study. Setting: The current study was conducted at inpatient medical wards located in the 2^nd and 3^rd floors at El Kasr Alini University Hospital, Egypt. Follow up of patients was performed at the outpatient medical clinics. Subjects: A convenient sample of 60 adult male and female patients with OSA that was collected over a period of 6 consecutive months and fulfilled the inclusion criteria (two equal intervention groups).Tools: Three tools were utilized to achieve the aim of the current study: 1) Demographic and medical related data sheet, 2) Apnea/ Hypopnea Index (AHI), and 3) The Pittsburgh Sleep Quality Index (PSQI) questionnaire. Results: Sniffing position group's OSA severity mean scores was lower than these in the side lying position group along the three post intervention measurements time. High statistically significant difference was observed between both groups regarding sleep quality in the 3^rdpost intervention period.  Conclusion: Significant improvement in obese patients' condition regarding OSA was observed with a remarkable decline in the severity mean scores among sniffing position group rather than side lying position group along the three post intervention periods. Recommendations: Provide educational sessions regularly regarding sniffing position therapy for obese patients with OSA and replication of such study on a larger sample is recommended.