This research was performed to evaluate “Productive traits, Biochemical parameters, Meat quality and the expression of related genes in different duck breeds". This experiment was conducted on 80 ducks (20 Pekin, 20 Star 53, 20 Muscovy, and 20 Mulard). Each breed was reared under the same ecological, managerial, and sanitary conditions from one day old until the end of the experiment (12th week of the age). The growth performance, biochemical characteristics, physicochemical parameters of meat, and gene expression of GH, IGF1, and calpain genes were analyzed and estimated. The findings showed that Mulard ducks had significantly greater (p<0.05) body weight (4234 g) followed by Muscovy (4029 g), Star 53 (3659 g), and Pekin (2961 g) although the feed conversion ratio (FCR) of Pekin ducks was higher (p<0.05) than others. Mulard had the longest shank, body length, keel length, and body circumference (8.28, 78.50, 20.21, and 38.60 cm, respectively) at the end of the experiment. Pekin ducks recorded the highest values of total cholesterol (TC), superoxide dismutase (SOD), and glutathione peroxidase (GPX). While, Mulard recorded the highest values of Glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and malondialdehyde (MDA). The lowest shear force value for breast and thigh muscles was observed in Muscovy ducks. GH, IGF-1 expression was higher in Mulard than other breeds. While, Calpain gene expression was higher (p<0.05) in Muscovy than in Mulard, Star 53, and Pekin. From the obtained results, it could be concluded that the observed highly productive traits in Mulard ducks might be attributed to the difference in gene expression related to growth. However, the good meat quality in Muscovy ducks was owing to the high expression of the Calpain gene.