With a purpose to investigate therapeutic efficacy of pentoxifylline (PTX) in Carbone tetrachloride (CCL4) caused hepatotoxicity taking silymarin (SYM) as standard hepatoprotective agent, twenty male adult Albino rats were employed in this study, split into four groups; group 1(control negative), group 2 (control positive) injected intraperitoneallywith 1.5 mg/kg of CCL4 after dilution in olive oil (1:7) three times per a week for 9 weeks, group 3, treated with 280 mg/kg BW of SYM and group 4, treated with 300 mg/kg BW of PTX. After the end of the experiment, serum biochemical analysis of aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), total protein and albumin, globulin, serum bilirubin levels were evaluated in different groups. Hepatic glutathione peroxidase (GPX), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured together with histopathological picture of all groups. Group 2revealed significant high levels of hepatic enzymes compared with control; these parameters were significantly decreased in response to treatment with either SYM or PTX. CCL4 administered rats showed marked reduction in albumin and total protein, with significant rise in globulin, serum bilirubin was elevated compared to control. Administration of SYM or PTX resulted in a significant improvement in different serum biochemical parameters where SYM was superior to PTX. Tissue scavenging capacities (GPX, CAT, SOD, and MDA) were evaluated in hepatic tissue, wheresignificant decrease in GPX, CAT, and SODwere observed in rats treated with CCL4, while hepatic MDA was significantly elevated when compared to healthy rats. Treatments with SYM or PTX improved the oxidative stress andSYM showing better outcome.Treatment with SYM or PTX in CCL4 treated male Albino rats defends liver as confirmed by the advancement of various oxidative and biochemical status as well as the recovery of hepatic structural solidity and assignment.