Breast cancer is a prevailing disease worldwide that requires effective and rational therapy. For this purpose, the use of various treatment modalities should be optimized according to the stage of disease and the risk: benefit ratio of the therapeutic agents employed in the patients. Although the therapies involved provide reduction in morbidity and mortality rates, monitoring is required to combat the resulting adverse drug reactions. This review would be helpful for healthcare professionals to address the multi factorial disease in accordance with its occurrence thereby providing rationalized therapy to the patients.Cancer is considered as a complex disease, which includes the changes in cell physiology, which ultimately lead to malignant tumors (Seyfried and Shelton, 2010). Cancer can result from abnormal differentiation of any of the different types of cells in the body, so there are hundreds of the same types of cancers which can differ substantially in their behavior and response to treatment