Beta
ManageSearchChatDiscover
401175

MicroRNAs in Breast Cancer: Insights into Diagnosis, Mechanisms, and Targeted Therapy

Article

Last updated: 07 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry and molecular biology

Abstract

Breast cancer (BC) is the most prevalent cancer amongst women and a major contributor to cancer-related death globally. It accounts for a significant portion of new cancer cases annually, reflecting its widespread prevalence and public health impact. Advances in molecular classification have identified subtypes such as luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC), which have revolutionized personalized treatment approaches. Early detection methods, including advanced diagnostic imaging and molecular biomarker profiling, have further contributed to improved survival rates. However, challenges such as metastasis to distant organs and recurrence of the disease after initial treatment remain significant obstacles to achieving long-term remission. Numerous studies have spotlighted the critical role of microRNAs (miRNAs) in BC pathogenesis. Through regulating gene expression, miRNAs influence various processes such as tumor growth, metastasis, and therapy resistance. Their biogenesis and mechanisms of action, particularly their roles in suppressing translation and promoting mRNA degradation, highlight their potential as diagnostic biomarkers and therapeutic targets. This growing understanding of miRNAs is paving the way for innovative and precise approaches to BC management.

DOI

10.21608/rpbs.2024.341890.1342

Keywords

breast cancer, Diagnosis, miRNAs, miRNA biogenesis, Treatment

Authors

First Name

Sameh

Last Name

Mohamed

MiddleName

H.

Affiliation

Biochemistry Department, Faculty of Pharmacy, The Egyptian Russian University, Cairo, Egypt

Email

sameh-hosam@eru.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Kamal

MiddleName

M.

Affiliation

Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt. Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Health Research Center of Excellence, Drug

Email

mohamed.kamal@bue.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Reda

MiddleName

M.

Affiliation

Department of Pharmacy, Kut University College, Al Kut, Wasit, 52001, Iraq Biochemistry Department, Faculty of Pharmacy, The Egyptian Russian University, Cairo, Egypt.

Email

ahmed.mustafa@alkutcollege.edu.iq

City

-

Orcid

-

First Name

Noha

Last Name

Mesbah

MiddleName

M.

Affiliation

Biochemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

noha_mesbah@pharm.suez.edu.eg

City

-

Orcid

0000-0002-8863-968X

First Name

Dina

Last Name

Abo-Elmatty

MiddleName

M.

Affiliation

Biochemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

dinawahadan@yahoo.com

City

Ismailia

Orcid

0000-0002-6074-2714

First Name

Asmaa

Last Name

Abdel-Hamed

MiddleName

R.

Affiliation

Biochemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

asmaa.ramdan@pharm.suez.edu.eg

City

-

Orcid

-

Volume

8

Article Issue

1

Related Issue

47567

Issue Date

2024-05-01

Receive Date

2024-12-10

Publish Date

2024-05-01

Page Start

241

Page End

249

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 8_Issue 1_Pages 241-249.pdf

PDF . 934.5kB

Link

https://rpbs.journals.ekb.eg/article_401175.html

Detail API

http://journals.ekb.eg?_action=service&article_code=401175

Order

401,175

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

MicroRNAs in Breast Cancer: Insights into Diagnosis, Mechanisms, and Targeted Therapy

Details

Type

Article

Created At

30 Dec 2024