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400342

Combatting antimicrobial resistance: Mechanisms, emerging therapies, and future directions

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Antimicrobials
Bacteria
Human Microbial Interactions
Medical Microbiology
Microbial-animal interactions
Microbiology
Molecular Biology
Multidrug Resistance
Virology

Abstract

Antimicrobial resistance, or AMR, is one of the major health challenges across the globe because of reduced effectiveness against bacteria, fungi, and viruses. This situation arises when there is significant interference with the effectiveness of antimicrobial agents-antibiotics, antifungals, and antivirals-that are considered essential for treatment. Antimicrobials act selectively against specific targets and metabolic processes of microorganisms. However, pathogens continuously evolve resistance mechanisms and complicate treatment efforts. The modes of action and the mechanisms of resistance are discussed, from the point of view of bacterial, fungal, and viral pathogens, with an overview of emerging therapeutic approaches, such as bacteriophage therapy and plant-derived antimicrobials. Understanding resistance modes is vital to fully harness existing antimicrobials, construct new synthetic agents, and promote responsible antimicrobial stewardship. It will showcase the existing knowledge and identify the gaps in research, therefore providing insight to guide future efforts in addressing AMR.

DOI

10.21608/mb.2024.400342

Keywords

Antimicrobial resistance, bacteriophage, Herbal medicine, Mechanism of Action, one health, sustainable development goals

Authors

First Name

Hebetullah

Last Name

Abdelshafey

MiddleName

ELsayed

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt.

Email

doctorheba97@gmail.com

City

-

Orcid

-

First Name

Mozan

Last Name

Abdalla

MiddleName

Ali

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt., School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

mozanfazaa2002@gmail.com

City

-

Orcid

-

First Name

Enas

Last Name

Eltayeb

MiddleName

Ezzeldein

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt., School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

enaseltayeb502@gmail.com

City

-

Orcid

-

First Name

Rafa

Last Name

Mohmmed

MiddleName

Omer

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt. , School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

rafaaomer277@gmail.com

City

-

Orcid

-

First Name

Alaa

Last Name

Younis

MiddleName

Abdelwahab

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt. , School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

yalooshy144@gmail.com

City

-

Orcid

-

First Name

Yusra Ahmed Musa

Last Name

Musa

MiddleName

Ahmed

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt. , School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

yusra7797310@gmail.com

City

-

Orcid

-

First Name

Ebaa

Last Name

Shekedrees

MiddleName

Iyad

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt. , School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

aba.eiad@icloud.com

City

-

Orcid

-

First Name

Israa

Last Name

Madani

MiddleName

Abdalgader

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt. , School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

israaabdalgadermadani@gmail.com

City

-

Orcid

-

First Name

Omnia

Last Name

Eltayeb

MiddleName

Abdullah

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt. , School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.

Email

omniakamoon5@gmail.com

City

-

Orcid

-

First Name

Yousra

Last Name

El-Maradny

MiddleName

A.

Affiliation

Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt. , Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications (SRTA-City), New Borg EL-Arab, Alexandria, 21934, Egypt. City of scientific research and technological applications

Email

hiph.ymaradny@alexu.edu.eg

City

-

Orcid

0000-0001-9501-8059

Volume

9

Article Issue

2

Related Issue

49870

Issue Date

2024-12-01

Receive Date

2024-10-06

Publish Date

2024-12-27

Page Start

96

Page End

114

Print ISSN

2357-0326

Online ISSN

2357-0334

Article File

MB_Volume 9_Issue 2_Pages 96-114.pdf

PDF . 1.1MB

Link

https://mb.journals.ekb.eg/article_400342.html

Detail API

https://mb.journals.ekb.eg/service?article_code=400342

Order

400,342

Publication Type

Journal

Publication Title

Microbial Biosystems

Publication Link

https://mb.journals.ekb.eg/

MainTitle

Combatting antimicrobial resistance: Mechanisms, emerging therapies, and future directions

Details

Type

Article

Created At

30 Dec 2024