Cyclosporine A (CsA) is a popular immunosuppressive medication for organ transplant recipients which its injection associated with oxidative stress. Moringa oleifera Seed oil (MOO) own high biological active ingredients, which makes it valuable medicinal plant-based dietary supplement that is used to address various nutrition-related wellness issues. The research is targeted to figure out the protective ability of MOO and encapsulated MOO (EMOO) against CsA toxicity, and assessing their antioxidant and anti-inflammation qualities. Rats (n=24) were separated into four groups: (1) received distilled water (control); (2) rats injected by CsA, (3) and (4) received MOO and EMOO coupled with CsA for 8 weeks. The oxidation, inflammation and minerals indices were measured in serum, liver and bone. Administration of MOO or EMOO significantly inhibited the development of bone loss in femur and tibia, improved hepatic and renal function, alleviate oxidative damage and inflammation compared to CsA rats. The histopathological examination of hepatic- and splenic tissue of MOO or EMOO showed improvement in tissue structure compared to CsA rats tissues. Encapsulating-MOO showed more effectiveness impact than MOO against CsA toxicity. Considering the potential antioxidant and anti-inflammatory characteristics of MOO, this research highlights its potential as a complementary therapeutic option when undergoing cyclosporine A.