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356625

Volatiles composition of fresh aroma and hydrodistilled volatile oil of Chrysopogon zizanioides roots growing in Egypt along with the cytotoxic activities of the hydrodistilled oi

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Chrysopogon zizanioides oil (CZO) is obtained from the roots of the C. zizanioides plant and it is frequently employed as a major odour contributor in the fragrance and aromatherapy industries. The hydrodistilled CZO was analyzed by GC/MS and compared to fresh sample aroma which was analyzed by headspace GC/MS method. The main constituents of the hydrodistilled oil were Khusimol (16.48%), aristol-1(10)en-9-ol (12.5%) and cyclocopacamphenol (7.69%). While headspace-GC/MS analysis identified bicyclo[5.2.0]nonane, 2-methylene-4,8,8-trimethyl-4-vinyl (14.17%), sativene (11.52%) and valencene (9.71%) as the major contributors to its fresh aroma. CZO was found to be active against two human cancer cell lines of lung (A549) and hepatocellular (HepG2) with IC50 32.2 and 37.6 µg/mL respectively using MTT assay. The results showed great similarity between the Egyptian oil and those available in the international market. Further studies are necessary for the full standardization and biological evaluation of the oil.

DOI

10.21608/ejchem.2024.269434.9311

Keywords

Chrysopogon zizanioides, Roots, oil, GC/MS, headspace, Cytotoxic activities

Authors

First Name

Mahmoud

Last Name

Arafat

MiddleName

-

Affiliation

Pharmacognosy department, Pharmacy, Heliopolis University, Cairo, Egypt.

Email

mahmoud.anter@hu.edu.eg

City

-

Orcid

0000-0002-5610-412X

First Name

Mohammed

Last Name

Khalil

MiddleName

-

Affiliation

Faulty of Pharmacy Cairo University

Email

mohamed.nabil@pharma.cu.edu.eg

City

-

Orcid

0000-0002-1134-1164

First Name

Engy

Last Name

Mahrous

MiddleName

A.

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University

Email

engy.abdelhamid@pharma.cu.edu.eg

City

-

Orcid

0000-0001-8355-6984

First Name

Seham

Last Name

El Hawary

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University

Email

seham.elhawary@pharma.cu.edu.eg

City

Cairo

Orcid

0000-0002-6823-1142

Volume

67

Article Issue

12

Related Issue

50716

Issue Date

2024-12-01

Receive Date

2024-02-11

Publish Date

2024-12-01

Page Start

299

Page End

305

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_356625.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=356625

Order

356,625

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Volatiles composition of fresh aroma and hydrodistilled volatile oil of Chrysopogon zizanioides roots growing in Egypt along with the cytotoxic activities of the hydrodistilled oil

Details

Type

Article

Created At

30 Dec 2024