Many researchers are interested in learning how to remove antibiotics from aqueous solutions because it is a major problem of pharmaceutical contamination for the development of bacterial resistance. In this study, adsorption studies were performed to remove antibiotics using agro-food waste [apple peels residue (APR)]. APR has such great potential filter for water treatment applications. A new generation of adsorbents has also been investigated for the elimination of the medicines tetracycline and amoxicillin. Several methods, like as scanning electron microscopy (SEM), energy dispersive spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR) and Brunauer−Emmett−Teller (BET) specific surface area , were used to investigate the physical and chemical parameters of the APR surface before and after adsorption. The results of the batch studies demonstrate that the Freundlich isotherm equations and pseudo-second order kinetic rate equations were better suitable models for simulating the adsorption with a maximum absorbance of 84.38% or 91.12% amoxicillin and tetracycline respectively. According to thermodynamic parameters, adsorption processes are absorptive and exothermic in nature where ΔH0 -1.57 and -0.773(kJ/mol) andΔS0 -0.011 ,-0.010 (KJ/mol) for Amoxicillin and tetracycline onto apple peels residue ,respectively . Last but not least, the data from this study also confirmed the n eed to pay attention to the use of agricultural waste materials as cheap lignocellulose sorbents that can replace expensive sorbents in wastewater treatment.