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380485

Design and synthesis of novel metallophthalocyanines via two step reactions as potential antimicrobial agents starting with new synthesized phthalonitrile derivatives: Complexati

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

New phthalonitrile derivatives 1-4 were considered as the key intermediates for the synthesis of new phthalocyanines. Their capacity to bind various transition metal and heavy metal cations was studied in methanol. The absorbance and conductivity were measured using UV spectrophotometry. Spectral and elemental investigations revealed the structures of the newly synthesized phthalocyanines. The complexes formed were analyzed, and their stability constants were determined through digital data processing. The ability of water to extract these compounds in dichloromethane was also examined. It was discovered that compound 1 had a lower affinity for metal picrates compared to compound 2-4, especially Fe(III). The stoichiometry of the complex was confirmed by conducting conductivity studies. The antimicrobial properties of the novel compounds were investigated, and it has been established that have compounds 9, 12 and 13 potent inhibitory activities against both Gram-positive and Gram negative bacteria and fungi.

DOI

10.21608/ejchem.2024.291095.9739

Keywords

Catalysis, Catalysts, Structure analysis, Stoichiometry, Complexation, Phthalonitriles, metallophthalocyanine derivatives

Authors

First Name

Donia

Last Name

Ben Salah

MiddleName

-

Affiliation

Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, Tunisia

Email

doniabensalah2017@gmail.com

City

tunis

Orcid

-

First Name

Waleed

Last Name

Koko

MiddleName

-

Affiliation

Department of Biology, College of Science, Qassim University, Qassim 51452, Saudi Arabia.

Email

wasyko2000@yahoo.com

City

-

Orcid

-

First Name

Sadeq M.

Last Name

Al-Hazmy

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

sadek.hazmy@gmail.com

City

alrass

Orcid

-

First Name

Lassaad

Last Name

Baklouti

MiddleName

-

Affiliation

Laboratoire d’Application de la Chimie aux Ressources et Substances Naturelles et à l’Environnement (LACReSNE/ LR05ES09)

Email

baklouti.l@gmail.com

City

tunis

Orcid

-

First Name

Rafik

Last Name

Gatri

MiddleName

-

Affiliation

Laboratoire de Synthèse Organique Sélective et Hétérocyclique. Evaluation Biologique LR17ES01 Faculté´ des Sciences de Tunis Faculté des Sciences de Tunis. Campus Universitaire 1092 Tunis, Université de Tunis El Manar, Tunisia

Email

-

City

-

Orcid

-

First Name

Naceur

Last Name

Hamdi

MiddleName

-

Affiliation

Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, Tunisia

Email

hamdi_naceur@yahoo.fr

City

denden

Orcid

-

Volume

67

Article Issue

11

Related Issue

50157

Issue Date

2024-11-01

Receive Date

2024-05-20

Publish Date

2024-11-01

Page Start

297

Page End

307

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 11_Pages 297-307.pdf

PDF . 2.9MB

Link

https://ejchem.journals.ekb.eg/article_380485.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=380485

Order

380,485

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Design and synthesis of novel metallophthalocyanines via two step reactions as potential antimicrobial agents starting with new synthesized phthalonitrile derivatives: Complexati

Details

Type

Article

Created At

30 Dec 2024