Epigenetic Modifications Among Children with Autism in Response to Phoenix dactylifera: An Intervention Study. - Egyptian Knowledge Bank

381089

Epigenetic Modifications Among Children with Autism in Response to Phoenix dactylifera: An Intervention Study.

Article

Last updated: 01 Jan 2025

Subjects

Abstract

This study explored the influence of the regular daily intake of 5 pieces of Ajwa dates fruit (Phoenix dactylifera) for four months on modifications of epigenetic factors related to autism. An interventional exploratory study was conducted on 31 autism-diagnosed children aged 3-12 years. Methylation-specific PCR was used to determine the methylation density of Olfactory receptor family 2 subfamily L member 13 (OR2L13), Reelin (RELN), Proline-Rich Transmembrane Protein 1 (PRRT1), and index of global methylation (Long interspersed nucleotide element-1, LINE-1). Quantitative real-time PCR was used to test the change in the expression of DNA methyltransferase 1 (DNMT1) and chromodomain helicase DNA-binding protein 8 (CHD8), the expression of plasma miR-146A and miR-146B. The study also investigated the clinical, microbial, and biochemical factors' responses to Phoenix dactylifera intake. In response to Ajwa dates fruit intake, a significant decrease in the expression of DNMT1, was shown in 64.5% of children (P=0.012). LINE-1, OR2L13, and PRRT1 showed significant changes in their methylation density. A significant decrease was observed in the pattern of RELN methylation status and the mean expression fold change of MiR-146A for 74.2% and 38.7% of children respectively. Phoenix dactylifera's regular intake plays a role in epigenetic modification among children with autism.

DOI

10.21608/ejchem.2024.314174.10234

Keywords

Ajwa dates fruit, autism, epigenetics modulation, DNA methylation, Expression of DNMT1 and CHD8, Expression modulation of plasma miR-146a and miR-146b, Phoenix dactylifera

Authors

View Authors

First Name

Ammal M.

Last Name

Metwally

MiddleName

Affiliation

Community Medicine Research Department/Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

ammal_mok@yahoo.com

City

Giza

Orcid

0000-0003-0575-5202

View Authors

First Name

Rehab

Last Name

Mosaad

MiddleName

Affiliation

Molecular Genetics and enzymology Department, Human Genetics and Genome Research Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt.

Email

drrehabmosaad@gmail.com

City

Orcid

0000-0002-5329-8897

View Authors

First Name

Walaa A.

Last Name

Basha

MiddleName

Affiliation

Biological Anthropology Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

walaa_researcher@yahoo.com

City

Orcid

0000-0002-4159-8139

View Authors

First Name

Ebtissam M.

Last Name

Salah El-Din

MiddleName

Affiliation

Child Health Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

ebtissam2006@yahoo.com

City

Orcid

View Authors

First Name

Marwa M.

Last Name

El-Sonbaty

MiddleName

Affiliation

Child Health Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

elsonbatymostafa@yahoo.com

City

Orcid

0000-0001-9965-4124

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First Name

Alshaimaa A.

Last Name

Elkhatib

MiddleName

Affiliation

Child Health Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

shimaadel80@yahoo.com

City

Orcid

0000-0001-7362-7216

View Authors

First Name

Marwa W.

Last Name

Abouelnaga

MiddleName

Affiliation

Child Health Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

marwaabouelnaga@gmail.com

City

Orcid

View Authors

First Name

Walaa

Last Name

Yousef

MiddleName

Affiliation

Biological Anthropology Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

wy2006nrc@yahoo.com

City

Orcid

0000-0002-6459-400X

View Authors

First Name

Walaa S.

Last Name

Mahmoud

MiddleName

Affiliation

Biological Anthropology Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

swalaa31@yahoo.com

City

Orcid

0000-0003-4222-6676

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First Name

Asmaa M.

Last Name

Fathy

MiddleName

Affiliation

Community Medicine Research Department/Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

asmaafathy.nrc@gmail.com

City

Orcid

View Authors

First Name

Ghada A.

Last Name

Elshaarawy

MiddleName

Affiliation

Community Medicine Research Department/Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

dr.ghada237@gmail.com

City

Orcid

0000-0001-7165-0594

View Authors

First Name

Manal A.

Last Name

Shehata

MiddleName

Affiliation

Child Health Department/ Medical Research and Clinical Studies Institute/National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt,

Email

dr_manalabdelkader@hotmail.com

City

Orcid

0000-0001-8749-7010

View Authors

First Name

Hanaa

Last Name

Attia

MiddleName

R. M.

Affiliation

Clinical and Chemical Pathology Department/Medical Research and Clinical Studies Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt

Email

hanarasmy2000@yahoo.com

City

Orcid

0000-0001-6401-8849

View Authors

First Name

Ehab R.

Last Name

Abdel Raouf

MiddleName

Affiliation

Department of Child with Special Needs/Medical Research and Clinical Studies Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt.

Email

ehabragaa@gmail.com

City

Orcid

0000-0002-0899-8261

View Authors

First Name

Amal

Last Name

Elsaied

MiddleName

Affiliation

Department of Child with Special Needs/Medical Research and Clinical Studies Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt.

Email

omar_elsaeid_amal@yahoo.com

City

Orcid

0000-0002-1569-7002

View Authors

First Name

Engy A.

Last Name

Ashaat

MiddleName

Affiliation

Clinical Genetics Dept./ Human Genetics and Genome Research Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt.

Email

nogy80@hotmail.com

City

Orcid

0000-0002-2116-1570

View Authors

First Name

Adel F.

Last Name

Hashish

MiddleName

Affiliation

Department of Child with Special Needs/Medical Research and Clinical Studies Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt.

Email

aladelomar@gmail.com

City

Doki

Orcid

0000-0001-9549-2973

View Authors

First Name

Nayra Sh.

Last Name

Mehanna

MiddleName

Affiliation

Probiotics Lab, the central laboratory network, Food industries and Nutrition Research Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt.

Email

mehanna2006@hotmail.com

City

Orcid

0000-0002-3475-7533

View Authors

First Name

Saleh M.

Last Name

Al Swailem

MiddleName

Affiliation

President of Ethq Agri. Develop. and Land Reclam. co. 33 Abdel Khaleq Tharwat St.Abdeen,Cairo,Egypt

Email

blo-123@hotmail.com

City

Orcid

View Authors

First Name

Sohair

Last Name

Salem

MiddleName

Affiliation

Molecular Genetics and enzymology Department, Human Genetics and Genome Research Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt.

Email

ssalem_nrc@hotmail.com

City

Cairo

Orcid

0000-0001-6811-431X

Volume

Article Issue

Related Issue

50157

Issue Date

2024-11-01

Receive Date

2024-08-21

Publish Date

2024-11-01

Page Start

219

Page End

237

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 11_Pages 219-237.pdf

PDF . 2.0MB

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https://ejchem.journals.ekb.eg/article_381089.html

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https://ejchem.journals.ekb.eg/service?article_code=381089

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381,089

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Epigenetic Modifications Among Children with Autism in Response to Phoenix dactylifera: An Intervention Study.

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Article

Created At

30 Dec 2024

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