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354599

Extraction and characterization of essential oil of Lavandula dentate L: Evaluation of its cytotoxicity and anticonvulsant activities in an epileptic model

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Abstract:

The Labiatae (Lamiaceae, Mentaceae) plant family, includes many shrubs and herbs as well as trees and vines, is economically significant. In the present study, aerial portions of Lavandula dentata L. (1753) were collected throughout the vegetative phase and stored in the herbarium for identification, authentication, and description. The analysis was carried out utilizing gas chromatography-mass spectrometry. The quantitative data were evaluated using peak area normalization without correction factors. Moreover, in vitro, cytotoxicity assay was examined, and anticonvulsant activity was tested in vivo using an epileptic rat model. The sulforhodamine B cell cytotoxicity assay was performed in vitro to assess cellular viability or cytotoxicity produced by the ethanolic extract and oil of L. dentata against HepG2 and Vero cells. In addition, seizure intensity scores and behavioral assessments were evaluaed and revealed that both essential oil and L. dentata extract reduced seizures, decreased distance and latency time in open field experiment, increased both grooming, rearing, and frequency of ambulation. Thus, the ethanolic extract or essential oil of L. dentata influences various behavioral domains and reduces depression-like symptoms in rats by inhibiting convulsion and seizure activity.

DOI

10.21608/ejchem.2024.280108.9524

Keywords

Lavandula dentate L, GC-MC, Cytotoxicity- Epilepsy- Seizure and Behavioral

Authors

First Name

Aziza

Last Name

Anter

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Science, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.

Email

gomana777@yahoo.com

City

-

Orcid

-

First Name

Eman S.

Last Name

Abdel-Rehiem

MiddleName

-

Affiliation

Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.

Email

em4salah@yahoo.com

City

-

Orcid

-

First Name

Areej

Last Name

Al-Khalaf

MiddleName

A.

Affiliation

Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia

Email

aaalkhalaf@pnu.edu.sa

City

-

Orcid

-

First Name

Abdelaziz S. A.

Last Name

Abuelsaad

MiddleName

-

Affiliation

Immunology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.

Email

elsaad22@science.bsu.edu.eg

City

-

Orcid

0000-0001-7037-0865

First Name

Gaber

Last Name

Shehab

MiddleName

M.G.

Affiliation

Department of Biochemistry, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Email

g.shehab@hotmail.com

City

Taif

Orcid

0000-0001-7037-0865

First Name

Ayman

Last Name

Abdel-Aziz

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, Fayoum University 63514, Fayoum, Egypt.

Email

ama25@fayoum.edu.eg

City

Fayoum

Orcid

0000-0001-9476-8923

First Name

Mohamed

Last Name

Abdel-Gabbar

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Science, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.

Email

hhmgabar@yahoo.com

City

Beni-Suef

Orcid

0000-0001-6573-2411

Volume

67

Article Issue

8

Related Issue

47534

Issue Date

2024-08-01

Receive Date

2024-03-28

Publish Date

2024-08-01

Page Start

665

Page End

687

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 8_Pages 665-687.pdf

PDF . 1.1MB

Link

https://ejchem.journals.ekb.eg/article_354599.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=354599

Order

354,599

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Extraction and characterization of essential oil of Lavandula dentate L: Evaluation of its cytotoxicity and anticonvulsant activities in an epileptic model

Details

Type

Article

Created At

30 Dec 2024