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356069

In Vitro Assessment of a Natural Monoterpene as an Antiviral Compound against Low Pathogenic Human Coronavirus 229E

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

The emergence of novel viruses, including SARS-CoV-2, has highlighted the need for effective antiviral treatments. This study aimed to evaluate the antiviral potential of pine oil and α-terpineol against low pathogenic coronavirus 229E (HCoV-229E), which serves as an alternative model for COVID-19. The study investigated the virucidal, adsorption, and multiplication inhibitory effects of pine oil and α-terpineol on HCoV-229E, as well as their impact on proinflammatory gene expression in an infected human colorectal adenocarcinoma cell line. Pine oil and α-terpineol exhibited high CC50 values and moderate in vitro inhibitory activity against HCoV-229E, with selectivity indices of 8.23 and 7.7, respectively. Plaque reduction tests demonstrated that these compounds effectively suppressed HCoV-229E during the adsorption and replication stages, and they were found to reduce the expression of proinflammatory genes associated with the development of a cytokine storm. The findings of this study suggest that pine oil and α-terpineol possess significant antiviral properties against HCoV-229E and warrant further investigation as potential therapeutic agents for viral infections, including COVID-19.

DOI

10.21608/ejchem.2024.285388.9639

Keywords

Pine oil, α -Terpineol compound, antiviral activity, Low pathogenic coronavirus 229E

Authors

First Name

Heba A.

Last Name

Dahdooh

MiddleName

-

Affiliation

Department of Chemistry of Natural and Microbial Products, National Research Centre, 12622-Dokki, Cairo, Egypt

Email

heba.dahdooh@gmail.com

City

Cairo

Orcid

-

First Name

Mohamed S.

Last Name

Taha

MiddleName

-

Affiliation

Research on Children with Special Needs Department, Institute of Medical Research and Clinical Studies, National Research Centre, 12622-Dokki, Cairo, Egypt.

Email

ms-taha@nrc.sci.eg

City

Cairo

Orcid

-

First Name

Sahar

Last Name

Abd Al-Daim

MiddleName

-

Affiliation

Environmental Virology Lab, 176, Water Pollution Research Department, Environment and Climate Change Institute, National Research Centre, 12622-Dokki, Giza, Egypt

Email

saharabdaldaim@yahoo.com

City

Egypt

Orcid

000000255916994

First Name

Nehal I.

Last Name

Ahmed

MiddleName

-

Affiliation

Environmental Virology Lab, 176, Water Pollution Research Department, Environment and Climate Change Institute, National Research Centre, 12622-Dokki, Giza, Egypt

Email

nehalismail84@gmail.com

City

Cairo

Orcid

-

First Name

Abdou K.

Last Name

Allayeh

MiddleName

-

Affiliation

Environmental Virology Lab, 176, Water Pollution Research Department, Environment and Climate Change Institute, National Research Centre, 12622-Dokki, Giza, Egypt

Email

drallayeh@yahoo.com

City

Cairo

Orcid

0000-0003-1550-4140

Volume

67

Article Issue

8

Related Issue

47534

Issue Date

2024-08-01

Receive Date

2024-04-26

Publish Date

2024-08-01

Page Start

537

Page End

545

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 8_Pages 537-545.pdf

PDF . 892.4kB

Link

https://ejchem.journals.ekb.eg/article_356069.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=356069

Order

356,069

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

In Vitro Assessment of a Natural Monoterpene as an Antiviral Compound against Low Pathogenic Human Coronavirus 229E

Details

Type

Article

Created At

30 Dec 2024