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336801

Synthesis and Characterization of Novel Phthalazin-1(2H)-one Hybrids with Anticipated Antibacterial Activity

Article

Last updated: 01 Jan 2025

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Tags

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Abstract

Herein, a phthalazine acetohydrazide derivative 4 was assembled and its behaviour towards carbon nucleophiles was thoroughly investigated. Subsequently, phthalazine derivative 4 was used as a valuable scaffold for synthesizing assorted heterocycles such as pyrazol, thiazolidine, and azetidine. Diversified reaction conditions and reagents were explored. The assigned structures of the assembled heterocycles were elucidated utilizing IR, 1H NMR, 13C NMR, MS, and elemental analysis. Finally, the newly assembled heterocycles were evaluated in vitro for their antibacterial activities.

DOI

10.21608/ejchem.2024.258130.9071

Keywords

acetohydrazide, thiazolidine, 2-Azetidinone, pyrazole, Antibacterial

Authors

First Name

Asmaa

Last Name

Mourad

MiddleName

Kamal

Affiliation

Department of Chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt

Email

akk00@fayoum.edu.eg

City

El Fayoum

Orcid

0000-0002-6417-8540

First Name

Ahmed

Last Name

Soliman

MiddleName

Yousef

Affiliation

Department of Chemistry, Faculty of Science, Fayoum University,Fayoum-Egypt

Email

ayk00@fayoum.edu.eg

City

Fayoum

Orcid

-

First Name

Abdelmoneim

Last Name

Makhlouf

MiddleName

Abdelsalam

Affiliation

Department of chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt

Email

aam11@fayoum.edu.eg

City

-

Orcid

-

First Name

Fatehia

Last Name

Mohammed

MiddleName

Korany

Affiliation

Department of Chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt

Email

fkt00@fayoum.edu.eg

City

-

Orcid

-

First Name

Samar

Last Name

Mohamed

MiddleName

Ahmed

Affiliation

Department of Chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt

Email

sam21@fayoum.edu.eg

City

-

Orcid

-

Volume

67

Article Issue

8

Related Issue

47534

Issue Date

2024-08-01

Receive Date

2023-12-25

Publish Date

2024-08-01

Page Start

351

Page End

366

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 8_Pages 351-366.pdf

PDF . 548.9kB

Link

https://ejchem.journals.ekb.eg/article_336801.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=336801

Order

336,801

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and Characterization of Novel Phthalazin-1(2H)-one Hybrids with Anticipated Antibacterial Activity

Details

Type

Article

Created At

30 Dec 2024