The current study was carried out in the Etay El-Baroud Agricultural Research Station, El-Beheira Governorate -Egypt's during two seasons. The purpose was assessing the effectiveness of four pesticides: buprofezin (Primo® 10% SC), spirotetramat (Movento® 10% SC), sulfoxaflor (Closer® 24% SC), and pyriproxyfen (Antiflay® 10% EC) against cucumber whiteflies, and determine the residues of the most effective pesticide against insect's egg in cucumber samples. The findings demonstrated that the tested pesticides were effective against whitefly eggs, nymphs, and adults. After 10 days of treatment, the tested pesticides considerably decreased the amount of egg masses. The most effective pesticide was Antiflay® 10% EC, while the numbers of whitefly nymphs and adults were most reduced by Primo® 10% SC. According to the dissipation kinetics data, the half-life of pyriproxyfen was 1.69 days. The residues of pyriproxyfen on cucumber were sharply decreased until 5 days of treatments and below the determination limit on 5th day, risk quotient (RQ) was higher than 1 until 3 days which indicates risk may be imposed during long-term consumption, but can be harvested without risk at pre-harvest interval.