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340016

Assessment of Urinary 8-Hydroxy-2-Deoxyguanosine as Oxidative DNA Damage for Diabetic Nephropathy

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Diabetic nephropathy (DN) is the main cause of chronic kidney disease, and represents the most common and serious complication of diabetes. 8-hydroxy-2′-deoxyguanosine (8-OHdG) emerged as a marker of DNA damage. Therefore, the study will assess association between urinary 8-OHdG and DN as early biomarker for DN. The study group included 100 volunteers, 50 cases with DN and 50 healthy control subjects matched in age with cases. The glycated hemoglobin (HbA1c), hsCRP, 25 OH vitD3 and urinary 8-OHdG levels were measured. Anthropometric measurements comprised body weight, height, waist circumference (WC) were measured. Significant increase in levels of hemoglobin (HbA1c), urinary 8-OHdG, BMI and WC in DN group compared to control. Significant positive linear relation was observed between WC and urinary 8-OHdG. Moreover, significant decline of vitamin D3 and significant increase of ESR and CRP was observed in DN cases. Oxidative damage had a role in the development of DN and increased levels of 8-Hydroxy-2-Deoxyguanosine is independently associated with WC. Our study found that, both ESR and hs-CRP were increased in DN that may be independent risk factors correlated with the severity of disease.

DOI

10.21608/ejchem.2024.256342.8999

Keywords

diabetic nephropathy, urinary 8-OHdG, HbA1c, CRP, ESR

Authors

First Name

Moushira

Last Name

Zaki

MiddleName

-

Affiliation

Biological Anthropology Department, Medical Research and Clinical Studies Institute–National Research Centre Cairo, Egypt.

Email

moushiraz@yahoo.com

City

Cairo

Orcid

0000-0002-5853-0050

First Name

Hanaa Reyad

Last Name

Abdallah

MiddleName

-

Affiliation

Biological Anthropology Department, Medical Research and Clinical Studies Institute–National Research Centre Cairo, Egypt.

Email

hanaareyad@yahoo.com

City

-

Orcid

0000-0002-9057-1290

First Name

Hisham

Last Name

Orban

MiddleName

-

Affiliation

Medical Biochemistry, Departments, Medical Research and Clinical Studies Institute – National Research Centre Cairo, Egypt.

Email

hishamorban1974@gmail.com

City

-

Orcid

0000-0002-1838-882X

First Name

Mohamed A.

Last Name

Shahba

MiddleName

-

Affiliation

Medical Biochemistry, Departments, Medical Research and Clinical Studies Institute – National Research Centre Cairo, Egypt.

Email

shahbamohamed@yahoo.com

City

-

Orcid

-

First Name

Wafaa

Last Name

Wafy

MiddleName

-

Affiliation

Departments of Public Health, Theodor Bilharz Research Institute

Email

wafywafa@yahoo.com

City

-

Orcid

0000-0001-8246-1887

First Name

Maha M

Last Name

Esmail

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Al-Azher University (for girls), Egypt.

Email

logeenwaleed5@gmail.com

City

-

Orcid

0000-0001-7871-0553

First Name

Mina

Last Name

Girgiss

MiddleName

Wassef

Affiliation

Medical Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo, Egypt.

Email

mwgnicola@hotmail.com

City

cairo

Orcid

0000-0003-0857-399X

First Name

Eman

Last Name

Youness

MiddleName

-

Affiliation

Medical Biochemistry, Departments, Medical Research and Clinical Studies Institute – National Research Centre Cairo, Egypt.

Email

hoctober2000@yahoo.com

City

-

Orcid

0000-0002-6492-1680

Volume

67

Article Issue

6

Related Issue

47152

Issue Date

2024-06-01

Receive Date

2023-12-18

Publish Date

2024-06-01

Page Start

405

Page End

408

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 6_Pages 405-408.pdf

PDF . 480.7kB

Link

https://ejchem.journals.ekb.eg/article_340016.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=340016

Order

340,016

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Assessment of Urinary 8-Hydroxy-2-Deoxyguanosine as Oxidative DNA Damage for Diabetic Nephropathy

Details

Type

Article

Created At

30 Dec 2024