Beta
ManageSearchChatDiscover
325744

Utilization of Multi Component Reactions in the Synthesis of 1,6-Naphthyridine Derivatives with Expected Biological Activity

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

We have achieved the diastereo selective synthesis of pyrano and furano naphthyridine derivatives through the utilization of Camphor sulfonic acid (CSA) as a catalyst in an ABB' type multi component coupling reaction involving 4-aminopyridine and cyclic enol ethers to form of pyrano and furano naphthyridine in high yields, primarily exhibiting cis diastereo selectivity. Notably, the addition of water as a reagent causes a shift in diastereoselectivity towards the trans isomer. Synthesized compounds were evaluated in vitro for their antimicrobial activities and molecular docking studies were performed.

DOI

10.21608/ejchem.2023.239412.8682

Keywords

Pyrano naphthyridine, furano naphthyridine, Camphor sulfonic acid, Cycloaddition, Organocatalyst

Authors

First Name

Abdullah Y.

Last Name

Abdullah Alzahrani

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail Assir, Saudi Arabia

Email

alzahrani@yahoo.com

City

-

Orcid

-

First Name

Amira

Last Name

Atef

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

Email

aaghonium@gmail.com

City

-

Orcid

-

First Name

Wassila

Last Name

Derafa

MiddleName

-

Affiliation

bChemistry Department, College of Science, Jouf University, Sakaka 2014, Saudi Arabia

Email

wassiladerafa@yahoo.com

City

-

Orcid

-

First Name

Nesrin

Last Name

Morsy

MiddleName

M.

Affiliation

Organometallic and Organometalloid Chemistry Department,National Research Centre, Cairo,12622, Dokki, Egypt.

Email

nesrinmorsy@yahoo.com

City

-

Orcid

0000-0003-3636-1767

Volume

67

Article Issue

6

Related Issue

47152

Issue Date

2024-06-01

Receive Date

2023-09-27

Publish Date

2024-06-01

Page Start

151

Page End

156

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 6_Pages 151-156.pdf

PDF . 613.4kB

Link

https://ejchem.journals.ekb.eg/article_325744.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=325744

Order

325,744

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Utilization of Multi Component Reactions in the Synthesis of 1,6-Naphthyridine Derivatives with Expected Biological Activity

Details

Type

Article

Created At

30 Dec 2024