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326841

Possible Ameliorative Effect Of Platelet Rich Plasma On Testicular Toxicity Of Silver Nanoparticles In Adult Albino Rats

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Last updated: 01 Jan 2025

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Abstract

Abstract
Silver nanoparticles (AgNPs) are being used increasingly in industrial and medical products owing to their unique properties. AgNPs can penetrate the testicular blood barrier and cause disorders in the male reproductive system. Platelet-rich plasma (PRP) contains many of growth factors that have regenerative and anti-inflammatory characteristics and have been used in different medical fields. In this work, we examined the toxicity of AgNPs and the possible ameliorative effect(s) of PRP on adult rat testes. Experimental study was conducted on 24 mature albino rat males that were allocated into four equal groups: G1: kept as control. G2: AgNPs-intoxicated group. G3: PRP–treated group. G4: recovery group. We collected samples for biochemical, immunohistochemical, histological, and genetic marker analysis. We found that AgNPs administration decreases glutathione (GSH), reproductive hormones, apoptotic marker; Bcl-2, germinal epithelial height, mRNA expression of claudin, and an increase in MDA level, TNF-α, lipid profile, thickening of the tubules' basement membrane with various histopathological defects, and an increase in mRNA expression of connexion-43. However, these negative effects were enhanced after PRP treatment. In conclusion, AgNPs changed the male reproductive system's biochemical and structural composition and administration of PRP effectively alleviating these changes. So, the scientific community ought to devote care to establishing procedures for eliminating toxicity, promoting health awareness, and reducing exposure to such materials.

DOI

10.21608/ejchem.2023.231340.8504

Keywords

Silver nanoparticle, platelet rich plasma, testicular toxicity, ROS, Connexion-43, Bcl-2

Authors

First Name

Marwa

Last Name

Shakra

MiddleName

El-Soudy

Affiliation

Department of Forensic Medicine and Clinical Toxicology. Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

marowelsoady.medg@azhar.edu.eg

City

-

Orcid

-

First Name

Nihal

Last Name

Mahmoud

MiddleName

Abdelmoneim

Affiliation

Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

nehalabdelmonem.medg@azhar.edu.eg

City

-

Orcid

0000-0003-1307-9320

First Name

Samah

Last Name

Ahmed

MiddleName

Gouda

Affiliation

Department of Histology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

semsemhisto@yahoo.com

City

-

Orcid

-

First Name

Safaa

Last Name

Elsharkawy

MiddleName

Abdelfattah

Affiliation

Department of Community Medicine and Occupational Health, Faculty of Medicine for Girls, Al-Azhar University,Cairo, Egypt.

Email

safaa.shark@gmail.com

City

-

Orcid

0000-0002-5569-5554

First Name

Amina

Last Name

Tolba

MiddleName

Mohamed

Affiliation

Department of Anatomy, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

aminamohamed.medg@azhar.edu.eg

City

-

Orcid

-

First Name

Rehab

Last Name

Masoud

MiddleName

Ali

Affiliation

Department of Forensic Medicine and Clinical Toxicology. Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

rehab.masoud22@gmail.com

City

-

Orcid

-

First Name

Sara

Last Name

Mousa

MiddleName

Nagdy

Affiliation

Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

saranagdy.medg@azhar.edu.eg

City

-

Orcid

0009-0009-3692-5535

First Name

Neveen

Last Name

Ebrahim

MiddleName

Adel

Affiliation

Department of Forensic Medicine and Clinical Toxicology. Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Email

neveenadel14@gmail.com

City

Cairo

Orcid

0000-0002-5569-5554

Volume

67

Article Issue

6

Related Issue

47152

Issue Date

2024-06-01

Receive Date

2023-08-26

Publish Date

2024-06-01

Page Start

67

Page End

76

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 6_Pages 67-76.pdf

PDF . 969.8kB

Link

https://ejchem.journals.ekb.eg/article_326841.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=326841

Order

326,841

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Possible Ameliorative Effect Of Platelet Rich Plasma On Testicular Toxicity Of Silver Nanoparticles In Adult Albino Rats

Details

Type

Article

Created At

30 Dec 2024