Lead poisoning has been classified as a non-traumatic brain injury. Exposure to lead during childhood may result in cognitive changes, memory disorders and requires neurodevelopmental monitoring till early adulthood. The present study investigated the ameliorative effect of black chia oil (COE) peppermint oil (POE) and their mixture against the neurological effects induced by lead acetate (LA) in growing albino rats. Eighty male rats were divided into eight groups, HCG: healthy control group; COCG: Chia oil group; POCG: peppermint oil group; COE+POE: Chia & peppermint oils mixture group; LACG: Lead acetate group; LA+COE: lead acetate + chia oil group; LA+POE: lead acetate+ peppermint oil group; LA+MOsE: lead acetate + chia and peppermint oils mixture group. Biochemical parameters including neural cell markers (BTChe, 5-HT and DA), antioxidant (SOD, CAT, TAC, GST and GPx), inflammatory (TNF-α and IL-6), oxidative stress (MDA), liver enzymes and kidney functions were investigated. Histopathology changes in brain and liver tissues was also detected. Supplementation of COE, POE and their mixture have proved to exerts an ameliorative effect against the neurological and histological disorders resulted from oral lead administration in growing rats. The synergistic effect of peppermint oil with chia oil resulted in a strong ameliorating effect against lead-intoxication.